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Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives
The N-terminal extracellular domain (ECD) of GLP-1R is important for GLP-1 binding and the crystal structure of the GLP-1/ECD complex was reported previously
What Clinical Trials Show The pivotal STEP trials that led to Ozempic's approval for weight loss did not identify leg pain as a frequent or serious adverse event
Dehydration represents another important contributor, as reduced oral intake due to nausea or early satiety combined with gastrointestinal losses can lead to volume depletion
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