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Regulatory Landscape The North American regulatory environment for GLP-1 receptor agonists centers on supply integrity and patient safety as branded products gain market prominence

Naltrexone-Bupropion is a combination of a mild inhibitor of dopamine and norepinephrine reuptake (Bupropion) with an agonist of the -opioid receptor (Naltrexone) that acts synergistically to activate pro-opiomelanocortin (POMC) neurons in the hypothalamic, in particular in the neurons in the arcuate nucleus (ARC), resulting in appetite suppression [96, 97]

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