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Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)
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Cardiovascular outcomes studies can play a role in understanding the long term impacts on co-morbidities when weight is lost with using medicine, Kumar told Medical News Today
c , Top twelve cellular component and top nine biological process ontologies identified using gene set enrichment (GSEA) analysis
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