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The activated EPAC2 can further activate Ras protein 1 and phospholipase C, which activate the IP3 and diacylglycerol (DAG) pathways and promote the release of Ca 2+ (16)
Documentation must show evidence of impaired circulation, such as diminished pulses, claudication, or vascular study results
Preclinical studies in rodents showed that GLP-1 receptor agonists, particularly at high doses, were associated with thyroid C-cell tumors (medullary thyroid carcinoma)
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