tirzepatide phase 3 mash and Newly released IIb 48-week liver biopsy data on # tirzepatide in #MASH Tirzepatide: Breakthrough in Obesity and

weight loss may take 34 weeks

Does everyone reach 15 mg

Abbreviations GLP-1 RAs: Glucagon-like peptide-1 receptor agonists GLP-1: Glucagon-like peptide-1 HR: Heart rate AF: Atrial fibrillation AFL: Atrial flutter VAs: Ventricular arrhythmias SCD: Sudden cardiac death T2DM: Type 2 diabetes mellitus BMI: Body mass index HbA1c: Glycated hemoglobin MACE: Major adverse cardiovascular event RR: Relative risk CI: Confidence interval RCT: Randomized controlled trial CVOT: Cardiovascular outcome trial SAE: Severe adverse effect Sc: Subcutaneous injection PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses FDA: Food and Drug Administration References Nauck MA, Meier JJ, Cavender MA, Abd El Aziz M, Drucker DJ

Better insulin sensitivity leads to lower insulin, which leads to lower androgen production, which leads to improved ovarian function