Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Nat Med 2019;25(7):1096-1103 doi:10.1038/s41591-019-0495-2 (Human pilot study, pasteurized form, 32 completers) Yoon HS, Cho CH, Yun MS, et al
It slows how quickly food leaves the stomach, creating a longer-lasting feeling of fullness
Key protocol components, including eligibility criteria, treatment strategies, assignment procedures, follow-up, outcome definitions, causal contrast, identifying assumptions and the data analysis plan, were translated into operational definitions using validated claims-based algorithms and observational analogs of key study design choices
These stacks aim to explore synergies between complementary pathways