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This requirement applies regardless of the agent being used
Individuals with Gastrointestinal Disorders: Such as Crohns disease, celiac disease, atrophic gastritis, or those who have had gastric bypass surgery or other stomach/intestinal resections, which can interfere with B12 absorption
cAMP promotes StAR-mediated transport of cholesterol into the mitochondria, where the steroidogenic enzyme cascade (P450scc, 3-HSD, CYP17, 17-HSD) converts it to testosterone
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