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Systemic anti-inflammatory signaling: TB-500 downregulates inflammatory cytokines across multiple tissue types, including muscle, tendon, cardiac, and neural tissue
In 2017, Dr
In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]
Taken together, this is the first study to describe the hepatic metabolome after ischemic AKI in a murine model and demonstrates that there is significant liver-kidney crosstalk after AKI
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