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MADRID Semaglutide (Wegovy) prevents major cardiac events including death in adults with overweight/obesity and cardiovascular disease (CVD), both with and without impaired kidney function, a subgroup analysis of the Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) trial shows

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Summary Stopping Tirzepatide triggers a physiological rebound rather than a simple lapse in willpower, with SURMOUNT-4 participants who switched to placebo after a 36-week induction regaining roughly 14 percent of their week 36 body weight over the following 52 weeks