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this warrants careful monitoring, particularly in individuals with pre-existing cardiac conditions Hypoglycaemia whilst retatrutide alone has a low intrinsic risk of hypoglycaemia, people with type 2 diabetes who are also taking insulin or sulfonylureas face an increased risk

GLP-1s are known to reduce both fat and muscle mass and discontinuation typically results in weight regainprimarily as fat massresulting in a less healthy body composition compared to treatment initiation

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Currently, a phase 3 clinical trial program for retatrutide (TRIUMPH) is underway to assess its safety and efficacy in different obese patient populations, including those with obstructive sleep apnea (OSA), T2D, diagnosed cardiovascular disease, osteoarthritis, and others