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When to Contact Your Healthcare Provider About Side Effects Severe or worsening nausea and vomiting beyond the first two weeks, inability to keep food or water down for more than a few hours, or signs of dehydration (dizziness, dry mouth, dark urine) require immediate medical attention
Due to the rapid renal clearance of small peptides like GLP-1, along with its deactivation by dipeptidyl peptidase 4 (DPP4), development of stable peptides, with an increased resistance to DPP4 was required (4)
PMID 22030019
Gradual Adjustment for Sensitive Patients Microdosing allows patients to ease into treatment while monitoring their tolerance: Smooth Transition: For individuals prone to sensitivity, starting low and slow provides the chance to adapt gradually, avoiding abrupt changes in appetite and energy
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