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The phase 2 trial was too small to detect rare events
While Im excited about the future of these drugs development, the side effect profile isnt worth the risk for otherwise healthy patients
In our previous video, we discussed how active GLP-1 (7-36) amide is easily degraded by DPP-4, causing issues with accurately measuring the hormone
It also has been demonstrated that prolactin induces increased expression of Pparg , Xbp1s , and GLUT4 in visceral and subcutaneous adipose tissue and elevated circulating adiponectin levels thereby increasing insulin sensitivity in mice (65)
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