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These combined effects lead to improved glycemic control and significant weight reduction
![tirzepatide vs semaglutide clinical trials vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data] Semaglutide vs. Tirzepatide: Which Wins](https://images.unsplash.com/photo-1631549916768-4119b2e5f926?crop=entropy&cs=tinysrgb&fit=max&fm=jpg&ixid=M3w5MTg4MzR8MHwxfHNlYXJjaHwxfHxtZWRpY2luZSUyMHBpbGxzJTIwcGhhcm1hY3l8ZW58MHwwfHx8MTc4NDUyNzIwOHww&ixlib=rb-4.1.0&q=80&w=1080)
Although in most cases, they are quite successful in producing substantial weight loss, many have regained weight after the medication was discontinued
![tirzepatide vs semaglutide clinical trials vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data] Semaglutide vs. Tirzepatide: Which Wins](https://www.endocrinologyadvisor.com/wp-content/uploads/sites/9/2024/04/CCH_HowToTreat_EA_ChronicWght_Table1_v3-1-1024x918.png)
Protein intake becomes particularly important during GLP-1 therapy because rapid weight loss can include muscle mass loss if protein consumption is insufficient
![tirzepatide vs semaglutide clinical trials vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data] Semaglutide vs. Tirzepatide: Which Wins](https://belite.com/wp-content/uploads/2025/06/July-2025-Blog-Post-Belite.png)
Yellow eyes are not a known or common side effect listed in the official drug information for semaglutide
![tirzepatide vs semaglutide clinical trials vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data] Semaglutide vs. Tirzepatide: Which Wins](https://www.news-medical.net/images/news/ImageForNews_823661_17628238374865977.jpg)
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