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Reactive oxygen species are natural byproducts of cellular metabolism and require ongoing regulation by antioxidant systems to help maintain balance and limit oxidative stress
10.1002/syn.20519 223
It is a limitation of the study that the midbrain organoid sets were generated from iPSCs from only one healthy donor and one PD patient
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Reference: FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
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