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With 8,847 participants over eight randomized controlled trials (RCTs), it was shown that 375 out of 1,000 people lost 10% of their body weight over the course of two years, with a net benefit probability of 0.91 in the second year and 0.97 in the first
Mechanistically, endothelial disruption increases sinusoid permeability, allowing hepatocytes to pass the endothelial barrier and enter liver parenchyma
Lancet 2: 1300-1304, 1987
Reported side effects include gastrointestinal symptoms such as nausea, vomiting, and delayed gastric emptying
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