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Hunger and food cravings often return to pre-treatment levels or may temporarily intensify as homeostatic mechanisms attempt to restore previous body weight set points

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8 The pharmaceutical industry has attempted to synthesize a drug that could have a positive effect on all the metabolic effects of obesity

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At the molecular level, preclinical models have suggested a multimodal mechanism

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Out of 4 patients with improvement in steatosis, 3 patients were on GLP1RA and one was on SGLT2 inhibitor (Table 3)

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