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The SURPASS clinical trial programme, which evaluated tirzepatide's safety and efficacy across thousands of participants, did not identify peripheral neuropathy or paraesthesia as a significant adverse event attributable to the medication, as summarised in the European Medicines Agency's European Public Assessment Report (EPAR)

Sulfur : Effective for reducing surface oil and drying out acne, sulfur is less irritating than benzoyl peroxide and often used in spot treatments and masks

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The main benefit of these medications is that, in large randomized controlled trials, there is an observed weight reduction of on average 15% over 18 months of use