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Incorporation of a trifluoromethyl group at the 6-position of the tetrahydropyran ring in omarigliptin (with a (2R, 3S, 5R, 6S) configuration) was found not only to enhance the pharmacokinetic profile in mice but also to maintain robust DPP-4 inhibitory activity
Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 15 The Relationship Between the Blood-Brain-Barrier and the Central Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors Authors Dong M , Wen S , Zhou L Received 21 May 2022 Accepted for publication 12 August 2022 Published 22 August 2022 Volume 2022:15 Pages 25832597 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Ming-Hui Zou Meiyuan Dong, 1 Song Wen, 1 Ligang Zhou 1, 2 1 Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, Peoples Republic of China
It also acts as an inhibitory neurotransmitter in the central nervous system, which can have mild calming effects
