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Tocotrienols have demonstrated inhibitory effects on the phosphorylation of the PI3k/Akt signaling pathway, resulting in the downregulation of key signaling molecules including endothelial nitric oxide synthase (eNOS), glycogen synthase kinase 3 (GSK3), and extracellular signal-regulated kinase (ERK)
Left, TT-OAD2 and Hep-P5 occupy a partially overlapping binding site but promote distinct conformations of the ECD and transmembrane bundle of the GLP-1R
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