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For type 2 diabetes, NICE guidance recommends reviewing GLP-1 therapy at 6 months, continuing only if HbA1c has reduced by at least 11 mmol/mol (1.0%) and weight has decreased by at least 3% of initial body weight
The ClC-Kb protein is encoded by the CLCNKB gene
Additional advantages include kidney protection and enhancements in liver function, which can mitigate obesity-related organ stress
Moreover, women tend to develop uremia symptoms at lower creatinine levels because they have lesser muscle mass and lower baseline serum creatinine levels
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