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This included a reduction in RAGE protein expression, suppression of key inflammatory cytokines (IL-6, IL-12, TNF-), and attenuation of matrix-degrading enzymes [9]

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The cyclic lactam bridge provides structural stability across a broad pH range , avoid strongly alkaline conditions above pH 9 that can promote lactam hydrolysis over extended incubation, and avoid oxidising conditions that could modify the Trp9 residue

Effect of N-acetylcysteine on cystatin C-based renal function after elective coronary angiography (ENABLE Study): a prospective, randomized trial