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The dosage of selenium in these trials ranged from 200 g/day to as high as 4800 g/day depending on the chemical form of selenium [95,96,97,98,99]
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It has been reported that Dox treatment induced senescence in both populations, accompanied by an increase in the expression of stemness and the multidrug resistance genes and an inhibition of Wnt/-catenin signaling Additionally, conditioned media from DOX-treated cells induces senescence in human induced pluripotent stem cell (hiPSC)-derived hepatocytes 11
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