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Wei et al., 2021)

Although in cognitively healthy individuals differences in BBB uptake have been observed with APOE genotypes as early as in individuals in their 30s (Yassine et al., 2017) in mice older ages may be required for such disturbances to occur (Alata et al., 2015)

The other half were euthanised with 2.5 ml/kg pentobarbitone followed by collection of blood, brain and spinal cord that were snap frozen