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But its likely not a good option if you have: Liver or kidney problems A bad infection Heart failure or had a recent heart attack An allergy to the medication Metformin has some common side effects, including: Nausea Diarrhea Vomiting Stomachache Loss of appetite Metallic taste in your mouth You can ease these problems if you take the medicine with food or if your doctor starts you at a low dose of the medicine and gradually raises it

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And third, both studies were done specifically in people with prediabetes, who already have disrupted blood sugar regulation