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As a GLP-1 receptor agonist, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, and slows gastric emptying

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Indications Semaglutide is indicated as monotherapy, when there is inadequate glycemic control with diet/exercise and when metformin is considered inappropriate due to intolerance or contraindications, and in combination with other glucose-lowering medication(s), including insulin, when these together with diet and exercise do not provide adequate glycemic control

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