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Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (55, 56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (5557)
The arginate (arginine salt) form demonstrates improved stability in gastric acid, making it better suited for oral administration with bioavailability exceeding 90% compared to roughly 3% for standard acetate taken orally
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