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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
Ladenstein R, Epp O, Bartels K et al (1979) Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 A resolution
Pregnancy Tirzepatide is not recommended during pregnancy
[20] [21] La refrigeracin es esencial porque los agonistas de GLP-1 son pptidos biolgicos sensibles a la temperatura
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