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Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity
The bioavailability and absorption kinetics of AOD-9604 following administration have been studied in both preclinical and clinical research
Excess B12 is excreted through urine as a water-soluble vitamin, reducing the risk of toxicity
Can be followed with a light oil such as squalane for enhanced absorption if desired
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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