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NICE NG246 (2025) recommends lower BMI thresholds (27.5 instead of 30, and 24.5 instead of 27) for South Asian, Chinese, Other Asian, Middle Eastern, Black African, and African-Caribbean backgrounds, because type 2 diabetes risk rises at lower BMIs in these populations 3,5
11,12 Across trials, they have consistently led to substantial weight loss, achieving reductions exceeding 10% of baseline body weight
Exploring Direct and Indirect Interactions The primary concern when combining medications is the potential for one drug to alter the effectiveness or safety profile of the other
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