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Biotinoyl Tripeptide-1 improves hair anchoring and reduces hair shedding, resulting in denser hair over time

However, its exclusivity is a primary point of controversy: it excludes approximately 10%15% of patients with clinically typical PD (e.g., carriers of LRRK2 or Parkin mutations, who often test negative on Syn seed amplification assays [Syn-SAAs]) from an NSD diagnosis, sparking criticism that its definition is overly narrow [9, 10]

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