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In Phase 2 clinical trials, participants receiving the highest dose of retatrutide (12 mg) lost an average of 24.2% of their body weight over 48 weeks
For example, semaglutide lowered kidney complications in people with type 2 diabetes and chronic kidney disease in a trial of more than 3,500 patients, and the FDA approved Ozempic for chronic kidney disease in people with type 2 diabetes in January 2025
The difference in results often comes down to how these medications work
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