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The medication requires gradual dose escalation over several months to minimize gastrointestinal side effects
For example, a 2017 study of 27 people with severe motor and intellectual disabilities found that carnitine levels were significantly lower in those who experienced constipation and that low levels were significantly related to constipation severity ( The study also showed that constipation severity decreased significantly after people received carnitine supplements of 4.522.5 milligrams per pound (mg/lb), or 1050 milligrams per kilogram (mg/kg), of body weight per day ( Summary A deficiency in carnitine is linked to constipation in those with severe intellectual and motor disabilities
People with a Family History of thyroid cancer: The FDA has issued a boxed (black box warning for semaglutide based on animal studies that revealed that semaglutide may increase the risk of thyroid cancer
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