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This hypothesis has been extensively validated by many in vitro studies in which psoriatic keratinocytes treated with thermal water presented alterations in cytokine 16, tumor necrosis factor (TNF)-alpha expression, vascular endothelial growth factor-A expression and secretion (Chiarini et al

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Until those trials exist, "promising mechanism", "positive topical data" and "proven injectable treatment" should not be sold as though they mean the same thing

638 Blocking 1R prevents DN in rats and is a potentially effective treatment for peripheral neuropathies in diabetes patients