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Orthostatic hypotension is specifically defined as a drop of 20 mmHg in systolic or 10 mmHg in diastolic blood pressure within 3 minutes of standing

The post hoc analysis of pooled data from the Semaglutide Treatment Effect in People with Obesity (STEP) 1, 2, 3, and 5 trials indicated that semaglutide treatment at 2.4 mg did not increase the risk of depressive symptoms or suicidal ideation compared to placebo, while demonstrating a statistically significant yet clinically negligible decrease in depressive symptoms [75]

10.1016/j.cgh.2009.07.016 113 SrivastavaA.WalterN.AtkinsonP