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However, as gallbladder disease is not an issue with sodium-glucose co-transporter-2 (SGLT-2) inhibitors (with similar weight loss) (89), and gallbladder events also occurred in GLP-1RA-treated patients well after weight reduction (90), other mechanisms are possibly in play
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Key Considerations Compounded semaglutide is not equivalent to FDA-approved semaglutide products Safety, efficacy, and quality may vary among compounded formulations Use requires medical supervision and ongoing monitoring Cost, availability, and formulation differ depending on the pharmacy and prescription Patients should discuss FDA-approved options, compounded alternatives, potential risks, and expected outcomes with their healthcare provider before starting treatment
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