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4 Instituto Nacional de Pediatra, Direccin de Investigacin, Mexico City, Mexico Correspondence: Sandra Nieto ([email protected]) Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-48 Background: Hereditary angioedema (HAE) is an autosomal dominant disorder caused by mutations in the C1 esterase inhibitor (C1-INH) gene, affecting approximately 1 in 50,000 people