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It occurs as a result of the proliferation of monoclonal mast cells
PubMed Lesho EP, Saullo L, Udvari-Nagy S
Moreover, as seen in HepaRG cells, higher cyclosporine concentrations (50 M) are associated with irreversible alterations in efflux and uptake activities, which ultimately resulted in the constriction of bile canaliculi and disorganization of the pericanalicular F-actin microfilaments (Sharanek et al., 2014)
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