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After initial phase, we recommend monthly maintenance treatments for 3-6 months

Together they create the comprehensive multi-pathway approach that single-modality detox cannot match

Exposure to ototoxic drugs, such as aminoglycoside antibiotics (such as streptomycin, gentamicin, acamicin, etc.), non-steroidal anti-inflammatory drugs, loop diuretics, antineoplastic drugs (such as cisplatin, nitrogen mustard, etc.), or inhalation of harmful gases (carbon monoxide, hydrogen sulfide, etc.), all can cause ARHL

Stimulation of TNFR1 induces certain conformational changes in the receptor, enabling its cytosolic portion to recruit several proteins to form the prosurvival complex I consisting of TNFR-associated death domain (TRADD), TNFR-associated factor 2 and 5 (TRAF2/5), RIPK1, cellular inhibitor of apoptosis proteins 1/2 (cIAP1/2), and linear ubiquitin chain assembly complex (LUBAC) (Nikoletopoulou et al., 2013