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Earlier oral GLP-1 drugs, such as semaglutide (Rybelsus), are peptide-based, which means they are easily broken down by stomach acid and digestive enzymes

Both drugs are GLP-1 receptor agonists that curb appetite and regulate blood sugar, especially when paired with healthy habits

What the trial found OASIS 4 was a 64-week, randomised, double-blind, placebo-controlled trial conducted across 22 sites in four countries

Even though there usually is remarkable variability in individual capacity for weight loss in response to pharmacological agents [36], these results might suggest that patients with poor metabolic long-term outcomes following BS are less likely to benefit from add-on pharmacotherapy