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4 How Mounjaro works Mounjaro activates two hormone receptors instead of one: Like Rybelsus, it activates the GLP-1 receptor It also activates GIP (glucose-dependent insulinotropic polypeptide), a second gut hormone involved in appetite regulation and blood sugar control This dual-action mechanism likely explains why tirzepatide produces greater weight loss and improvements in blood sugar in clinical trials than GLP-1-only medications
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Nine participants in the treatment group recorded at least one serious adverse event compared with 11 given placebo
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