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The coordinate increase of the two enzymes in the glutathione oxidation/reduction cycle indicates that there was increased usage and recycling of glutathione in susceptible plants even though the total amount of glutathione remained stable

It counteracts the effects of inflammatory cytokines that promote muscle degradation

Nonetheless, we show that following GSH depletion, the repression of lipogenic gene expression and serum triglyceride levels is dependent on NRF2 activation

Acknowledgments We extend our deepest gratitude to the School of Medicine at Universidad San Francisco de Quito (USFQ), the Instituto de Investigaciones en Biomedicina (USFQ), and the Mito-Act Research Consortium in Quito, Ecuador, for their unwavering support of our research and initiatives.We also wish to express our special thanks to the Instituto de Neurociencias for their invaluable support during Kevin Zambranos Ph.D