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Similarly, in mesangial cells, GLP-1 receptor agonists have been shown to suppress either high-glucose-induced or AGEs-induced pro-fibrotic signalling pathways, including NF-B activation and TGF-1 expression, leading to reduced ECM deposition [60,61], and to suppress their proliferation via AMPK activation [62]

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Pairing an apple with almond butter provides fiber from the fruit and protein plus healthy fats from the nuts

Their unique dual-action mechanism targets both GIP and GLP-1 receptors, helping to regulate appetite, improve metabolism, and support greater fat reduction compared to medications that target only GLP-1 receptors