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doi: 10.1038/s41420-024-01863-1 11 MouYWangJWuJHeDZhangCDuanCet al
(2018) reported that GLP-1 induces either an increase or a decrease of spontaneous firing rate in GLP-1R expressing BNST neurons
Endocrinol Diabetes Obes
Other long-term considerations include gastrointestinal adaptation (most patients find side effects diminish significantly after the first 3-6 months), nutritional deficiencies that can develop with prolonged reduced caloric intake, and the psychological adjustment of maintaining a dramatically different body weight and relationship with food
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