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doi: 10.1038/s41580-024-00703-5 187 WangHLiuDZhengBYangYQiaoYLiSet al

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Pirfenidone Pirfenidone (5-methyl-1-phenylpyridin-2(1 H)-one) is a non-peptide synthetic molecule with high oral bioavailability, that exerts anti-fibrotic, anti-inflammatory, antioxidant, and apoptosis-regulating effects [213, 214]

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Severe abdominal pain, gallbladder symptoms, persistent vomiting, and dehydration require symptom-based review

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Sorafenib, an FDA-approved multi-target kinase inhibitor, is the first-line systemic therapy for advanced HCC

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