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PMID 39987697
The 39 amino acid sequence of tirzepatide shares similarity with that of GIP, GLP-1 and exendin-4 and is characterized by an acyl chain attached to the lysine residue at position 20 contributing to albumin binding and half-life extension to 5 days [41]
That leads to constipation, and more straining when opening your bowels, which in turn causes piles, small tears and anal skin tags. Constipation and straining are among the most common triggers for haemorrhoids, particularly when prolonged over weeks or months
Thus, manufacturers may prefer one route over another
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