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A 2024 study in monkeys found metformin reversed molecular aging markers (e.g., reduced inflammation, improved DNA repair) in multiple organs, effectively making their tissues 6 years younger. Lifespan : The evidence is mixed: In mice, metformin extended lifespan by 14% when started young, but had minimal effects in older mice, a 2013 study found

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As of early 2025, one clinical trial (NCT05751668) was recruiting participants with advanced-stage breast cancer to explore the effects of GM1 for the prevention of paclitaxel-induced CIPN

Furthermore, we will systematically examine the specific impact of smoking on key liver pathologies, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), chronic viral hepatitis, primary biliary cholangitis (PBC), and hepatocellular carcinoma (HCC)