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The pathway operates through both canonical (RBP-J/CBF-1dependent) and noncanonical mechanisms
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DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss
Such increased GH levels may modulate physiological and molecular markers associated with muscle tissue development, lipid metabolism, age-related cellular processes, and metabolic function in research models
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