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Muscles are very metabolically active tissues, meaning they burn more calories than fat, even at rest
Applying firm pressure for 1020 seconds after injecting and warming the medication to room temperature for 1530 minutes before use can also help reduce the likelihood of bruising
This pharmacokinetic profile means that dose adjustments are generally not required in patients with renal impairment, although clinical experience in end-stage renal disease (ESRD) and dialysis is limited, so caution and monitoring are advised in these populations
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