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Have complex medical histories: Individuals with a history of medullary thyroid carcinoma, MEN 2 syndrome, pancreatitis, severe gastrointestinal disease, or who are pregnant or nursing should not use GLP-1 medications

Despite appearing promising, it remains unclear whether the positive effects of triple agonists differ from those seen in dual GLP-1/GIP agonists

The peak discomfort window is typically **1248 hours post-injection**, though some patients especially during dose escalation feel it for up to 72 hours ([FDA Wegovy Prescribing Information]( Nausea is most intense during the early weeks of treatment and during each dose increase

The fix: inject 1-2 cm below the kneecap, directly over the patellar tendon