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Low-grade chronic inflammation and immunological imbalance facilitate a bidirectional association between obesity and immune-mediated dermatoses An excess of dysfunctional adiposity contributes to the inflammatory state that characterizes patients with obesity.14 As low-grade inflammation underlies obesity, PsO, and HS (Fig

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That is a stability and delivery advantage in the upper skin, not a route into the dermis, and any cream described as reaching that far is overstating what a cream does